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Scopus Presentation on Launch of Duet Therapeutics, its Wholly-Owned Subsidiary Focused on Immuno-Oncology
October 7, 2021
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Scopus BioPharma to Present at MicroCap Rodeo’s Fall Harvest Best Ideas Conference
October 1, 2021
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Duet Therapeutics, a Scopus BioPharma Company (Mechanism of Action)
September 27, 2021
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Scopus BioPharma to Present at the Benzinga Healthcare Small Cap Conference
September 23, 2021
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Scopus BioPharma to Present at H.C. Wainwright 23rd Annual Global Investment Conference
September 9, 2021
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Scopus BioPharma’s Subsidiary — Duet Therapeutics — to Present at the 14th Annual RNA Consortium Meeting
September 3, 2021
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Scopus BioPharma Expands Immunotherapy Pipeline with Acquisition of Olimmune
June 30, 2021
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Myeloid cell-targeted STAT3 inhibition sensitizes head and neck cancers to radiotherapy and T cell-mediated immunity
Journal of Clinical Investigation
November 24, 2020
Dayson Moreira, Sagus Sampath, Haejung Won, Seok Voon White, Yu-Lin Su, Marice Alcantara, Chongkai Wang, Peter Lee, Elli Maghami, Erminia Massarelli, & Marcin Kortylewski
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STAT3 inhibition combined with CpG immunostimulation activates antitumor immunity to eradicate genetically distinct castration-resistant prostate cancers
Clinical Cancer Research
December 1, 2018
Dayson Moreira, Tomasz Adamus, Xingli Zhao, Yu-Lin Su, Zhuoran Zhang, Seok Voon White, Piotr Swiderski, Xin Lu, Ronald DePinho, Sumanta Pal, & Marcin Kortylewski
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B cell lymphoma immunotherapy using TLR9-targeted oligonucleotide STAT3 inhibitors
Molecular Therapy
January 15, 2018
Xingli Zhao, Zhuoran Zhang, Dayson Moreira, Yu-Lin Su, Haejung Won, Tomasz Adamus, Zhenyuan Dong, Yong Liang, Hongwei Yin, Piotr Swiderski, Raju Pillai, Larry Kwak, Stephen Forman, & Marcin Kortylewski
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Myeloid cells as a target for oligonucleotide therapeutics: turning obstacles into opportunities
Cancer Immunology, Immunotherapy
February 18, 2017
Marcin Kortylewski & Dayson Moreira
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Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia
Blood
March 31, 2016
Qifang Zhang, Dewan Md Sakib Hossain, Priyanka Duttagupta, Dayson Moreira, Xingli Zhao, Haejung Won, Ralf Buettner, Sergey Nechaev, Marcin Majka, Bin Zhang, Qi Cai, Piotr Swiderski, Ya-Huei Kuo, Stephen Forman, Guido Marcucci, Marcin Kortylewski
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TLR9-targeted STAT3 silencing abrogates immunosuppressive activity of myeloid-derived suppressor cells from prostate cancer patients
Clinical Cancer Research
August 15, 2015
Dewan M. S. Hossain, Sumanta K. Pal, Dayson Moreira, Priyanka Duttagupta, Qifang Zhang, Haejung Won, Jeremy Jones, Massimo D'Apuzzo, Stephen Forman, and Marcin Kortylewski
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Revisiting STAT3 signalling in cancer: new and unexpected biological functions
Nature Reviews Cancer
October 24, 2014
Hua Yu, Heehyoung Lee, Andreas Herrmann, Ralf Buettner, & Richard Jove
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Leukemia cell-targeted STAT3 silencing and TLR9 triggering generate systemic antitumor immunity
Blood
January 2, 2014
Dewan Md Sakib Hossain, Cedric Dos Santos, Qifang Zhang, Anna Kozlowska, Hongjun Liu, Chan Gao, Dayson Moreira, Piotr Swiderski, Agnieszka Jozwiak, Justin Kline, Stephen Forman, Ravi Bhatia, Ya-Huei Kuo, Marcin Kortylewski
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TLR9 signaling in the tumor microenvironment initiates cancer recurrence after radiation therapy
Cancer Research
December 1, 2013
Chan Gao, Anna Kozlowska, Sergey Nechaev, Haiqing Li, Qifang Zhang, Dewan M S Hossain, Claudia M Kowolik, Peiguo Chu, Piotr Swiderski, Don J Diamond, Sumanta K Pal, Andrew Raubitschek, Marcin Kortylewski
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Intracellular processing of immunostimulatory CpG-siRNA: toll-like receptor 9 facilitates siRNA dicing and endosomal escape
Science Direct
September 28, 2013
Sergey Nechaev, Chan Gao, Dayson Moreira, Piotr Swiderski, Agnieszka Jozwiak, Claudia M Kowolik, Jiehua Zhou, Brian Armstrong, Andrew Raubitschek, John J Rossi, Marcin Kortylewski
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TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells in vivo
Blood
February 21, 2013
Qifang Zhang, Dewan Md Sakib Hossain, Sergey Nechaev, Anna Kozlowska, Wang Zhang, Yong Liu, Claudia M Kowolik, Piotr Swiderski, John J Rossi, Stephen Forman, Sumanta Pal, Ravi Bhatia, Andrew Raubitschek, Hua Yu, Marcin Kortylewski
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STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors
Nature Medicine
November 21, 2010
Heehyoung Lee, Jiehui Deng, Maciej Kujawski, Chunmei Yang, Yong Liu, Andreas Herrmann, Marcin Kortylewski, David Horne, George Somlo, Stephen Forman, Richard Jove, Hua Yu
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Targeting STAT3 in the myeloid compartment drastically improves the in vivo antitumor functions of adoptively transferred T cells
Cancer Research
October 1, 2010
Andreas Herrmann, Marcin Kortylewski, Maciej Kujawski, Chunyan Zhang, Karen Reckamp, Brian Armstrong, Lin Wang, Claudia Kowolik, Jiehui Deng, Robert Figlin, Hua Yu
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STATs in cancer inflammation and immunity: a leading role for STAT3
Nature Reviews Cancer
November 1, 2009
Hua Yu, Drew Pardoll, Richard Jove
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TLR agonist-STAT3 siRNA conjugates: cell-specific gene silencing and enhanced antitumor immune responses
Nature Biotechnology
September 13, 2009
Marcin Kortylewski, Piotr Swiderski, Andreas Herrmann, Lin Wang, Claudia Kowolik, Maciej Kujawski, Heehyoung Lee, Anna Scuto, Yong Liu, Chunmei Yang, Jiehui Deng, Harris S Soifer, Andrew Raubitschek, Stephen Forman, John J Rossi, Drew Pardoll, Richard Jove, & Hua Yu
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TLR9 activation of STAT3 constrains its agonist-based immunotherapy
Cancer Research
March 3, 2009
Marcin Kortylewski, Maciej Kujawski, Andreas Herrmann, Chunmei Yang, Lin Wang, Yong Liu, Rosalba Salcedo, and Hua Yu
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Regulation of the IL-23 and IL-12 balance by STAT3 signaling in the tumor microenvironment
Cancer Cell
February 3, 2009
Marcin Kortylewski, Hong Xin, Maciej Kujawski, Heehyoung Lee, Yong Liu, Timothy Harris, Charles Drake, Drew Pardoll, Hua Yu
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Crosstalk between cancer and immune cells: role of STAT3 in the tumor microenvironment
Nature Reviews Immunology
January 1, 2007
Hua Yu, Marcin Kortylewski, & Drew Pardoll
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Inhibiting STAT3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
Nature Medicine
November 20, 2005
Marcin Kortylewski, Maciej Kujawski, Tianhong Wang, Sheng Wei, Shumin Zhang, Shari Pilon-Thomas, Guilian Niu, Heidi Kay, James Mulé, William G Kerr, Richard Jove, Drew Pardoll & Hua Yu
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Regulation of the innate and adaptive immune responses by Stat3 signaling in tumor cells
Nature Medicine
December 21, 2003
Tianhong Wang, Guilian Niu, Marcin Kortylewski, Lyudmila Burdelya, Kenneth Shain, Shumin Zhang, Raka Bhattacharya, Dmitry Gabrilovich, Richard Heller, Domenico Coppola, William Dalton, Richard Jove, Drew Pardoll, Hua Yu
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